We are interested in understanding molecular mechanisms that dictate tumor growth, metastasis initiation and progression. We study both cancer cell intrinsic properties and the contribution of the tumor microenvironment, so that the therapeutic potential of targeting these cells as an anti-cancer approach can be realized.
Our approach is multidisciplinary in nature combining strengths of functional genomics such as genome-wide mRNA, microRNA and epigenome profiling, RNAi mediated gene silencing to mouse genetic models to dissect molecular and cellular pathways of BM-mediated tumor angiogenesis.