We are interested in understanding the cellular and molecular mechanisms that dictate primary tumor growth, metastasis initiation and progression. Our approach is multidisciplinary in nature integrating strengths of functional genomics (gene expression, microRNA, epigenome)  with mouse genetic models of human cancer. A major aim is to rapidly confirm insights obtained from these investigations in  clinical settings in collaboration with expert clinicians.

A major focus of the laboratory is also to determine the contribution and biological role of bone marrow-derived microenvironments in these processes.

The main areas of  research  are:

  • Role of bone marrow cells in tumor growth and metastasis

  • Targeting the BM-derived tumor microenvironment as an anticancer approach 

  • Molecular Mechanisms of  metastasis initiation and progression.
  • Genome-wide analysis using massively parallel sequencing and RNAi library screens.

FOR DETAILS VISIT THE MITTAL LAB  WEBPAGE -  CLICK HERE

POSITIONS OPEN FOR POST DOCTORAL  FELLOWS, CLINICAL FELLOWS, COMPUTATIONAL FELLOWS-  CLICK HERE

 

Principal Investigator: Vivek Mittal, Ph.D

Associate Professor of Cardiothoracic Surgery

Department of Cell and Developmental Biology

Director, Lehman Brothers Lung Cancer Laboratory

Cornell University Medical Center

1300 York Avenue

525 East,  68th Street

Building A, Room 603C

New York, New York 10065

PHONE              212-756-9401                

LAB PHONE:                212-746-9400       

FAX: 212-746-9393

E-mail: vim2010@med.cornell.edu